| Course title | |||||
| 分子生物学Ⅱ [Molecular Biology Ⅱ] | |||||
| Course category | technology speciality courses,ets. | Requirement | Credit | 2 | |
| Department | Year | 2～4 | Semester | Spring | |
| Course type | Spring | Course code | 022108 | ||
| Instructor(s) | |||||
| 吉野 知子 [YOSHINO Tomoko] | |||||
| Facility affiliation | Faculty of Engineering | Office | Email address | ||
| Course description |
| Molecular biology II is the advanced course of molecular biology I. With the comparison to the prokaryotes on the following basic aspects, the students will learn 1) the structure of genome and gene, 2) DNA replication, transcription, and translation, and 3) the regulation of gene expression in eukaryotes. This course will further help the students to understand the molecular biology of the cells containing cancer-related genes. |
| Expected Learning |
| By the end of the course, the students should have to understand the biological phenomenon of eukaryotes on the molecular level. |
| Course schedule |
|
Unit 1 Introduction Unit 2 Structure of chromosome In contrast to prokaryotic organism, the DNA of eukaryotic organism is enclosed by the nuclear membrane. The DNAs are packaged and ordered by the highly alkaline proteins, histone, to form the chromosome. In this lesson/unit, the mechanism for the chromosome formation will be generally discussed. Unit 3 Transcription In this lesson/unit, the mechanism of RNA transcription from DNA including the transcription factor will be discussed. Unit 4-6 Regulation of gene expression I-III The eukaryotic transcription apparatus and transcription factors which are essential for the regulation of gene expression are distinct from those in prokaryotes. In this lesson/unit, the mechanism of gene expression regulation in eukaryotes will be generally discussed via the comparison to prokaryotes. Unit 7 Topics Unit 8 Mid-term examination Unit 9 Replication and repair In this lesson/unit, the mechanism of DNA replication and repair including the mismatch repair (?), excision repair, and recombinational repair. Unit 10,11 Translation I,II In this lesson/unit, the post-transcriptional modification of RNA, mechanism of eukaryotic translation and its differences from the prokaryotes will be discussed. Unit 12 Development of cancer Unit 13 Molecular mechanism of signal transduction Unit 14 Summary Unit 15 Final examination |
| Prerequisites |
| The students should have already completed the basic molecular biology and molecular biology 1. The students who are taking the biochemical 1 & 2 would be preferred. |
| Required Text(s) and Materials |
| Prints of the course content |
| References |
| Bruce Alberts, Alexander Johnson, Julian Lewis, Martin Raff, Molecular Biology of the Cell 5E, Garland Science. |
| Assessment/Grading |
| The students will be evaluated by their performances on the reports, the mid-term examinations, and the final examinations. |
| Message from instructor(s) |
| The students will expand their knowledge on molecular biology, if they well understand the gene regulation in prokaryotes which were taught on Molecular biology I. Furthermore, I hope the students can always explain what they have learned in this course generally in their own words. |
| Course keywords |
| Eukaryotes, DNA replication, transcription and translation, chromosome, regulation of gene expression, transcription factor |
| Office hours |
| 13:00 － 14:00, Monday |
| Remarks 1 |
| Remarks 2 |
| Related URL |
| Lecture Language |
| Language Subject |
| Last update |
| 4/12/2017 6:41:54 PM |