Course title
有機化学Ⅱ   [Organic ChemistryⅡ]
Course category	technology speciality courses,ets.	Requirement		Credit	2
Department		Year	1～4	Semester	Fall
Course type	Fall	Course code	021215
Instructor(s)
山崎 孝   [YAMAZAKI Takashi]
Facility affiliation	Faculty of Engineering	Office		Email address

Course description

a. Aim: Organic Chemistry is important not only as a basis of organic synthesis but also all the science and technology concerning organic materials which include metabolic biotransformation and electronic property of organic molecules. Organic Chemistry II is a part of Organic Chemistry course which consists of Organic Chemistry I ? IV. Organic Chemistry course aims at understanding of fundamentals of organic chemistry. b. Outline: In this lecture, the structures, properties, and reactivity of alkenes, alkynes, alkyl halides, conjugated dienes, and aromatic compounds are discussed. Some of the fundamental concepts in organic chemistry such as “nucleophilic substitution”, “？-elimination”, “kinetic control and thermodynamic control”, “resonance”, and “aromaticity” are also expounded.

Expected Learning

To understand the structures, properties, and reactivity of alkenes, alkynes, alkyl halides, conjugated dienes, and aromatic compounds and the important concepts related to the chemistry of these compounds.

Course schedule

1. Alkenes - reactions and preparation I Preparation of alkenes, reactions of alkenes with electrophiles which include addition of halogens and hydrogen halides, and hydration are expounded. 2. Alkenes - reactions and preparation II Epoxydation, oxidative cleavage, cyclopropanation of alkenes, stereochemical course of addition of electrophiles to alkenes are expounded. 3. Alkynes I Naturally occurring alkynes are explained. Preparation, electronic structure, nomenclature, and addition reaction of alkynes are expounded. 4. Alkynes II Oxidation, reduction, and hydration of alkynes are explained. Generation and reaction of acetylides are discussed. 5. Alkyl halides I Nomenclature and Structure of alkyl halides and preparation of Grignard and Gilmann reagents are explained. 6. Alkyl halides II Preparation of alkyl halides, Stability of allylic radicals, resonance forms, and resonance theory are expounded. 7. Nucleophilic substitution I Walden inversion, synthetically useful SN2 reactions are explained. Substrates, leaving group, solvents used in SN2 are expounded in detail. 8. Nucleophilic substitution II Relationship between nucleophilicity and basicity, and SN1 reactions are explained. 9. Comprehensive exercise 10. Elimination reactions E2 and E1 reactions are discussed. 11. Conjugated dienes Stability of conjugated dienes, Diels-Alder reaction, kinetic control, and thermodynamic control are expounded. 12. Aromatic compounds I Nomenclature of aromatic compounds, structure and stability of benzene are explained. 13. Aromatic compounds II Aromaticity, Huckel 4n+2 rule, aromatic ions, heterocyclic aromatic compounds, polycyclic aromatic compounds are expounded. 14. Reactions of aromatic compounds I Electrophilic aromatic substitution is expounded. The main topics are nucleophilicity of aromatic compounds and regioselectivity of the reaction of substituted benzenes. 15. Reactions of aromatic compounds II Nucleophilic aromatic substitution, structure and reactivity of benzyne, and oxidation and reduction of aromatic compounds are discussed.

Prerequisites

Students who want to take this course must take Organic Chemistry I in advance.

Required Text(s) and Materials

John McMurry, “Organic Chemistry 9th Edition” If the corresponding 8th edition was already bought, then it is OK to use it.

References

Assessment/Grading

Midterm examination (50%) and final examination (50%)

Message from instructor(s)

Course keywords

Office hours

Koganei campus, Building 1, Room S210, 16:00-17:00 on every Monday

Remarks 1

Remarks 2

Related URL

Lecture Language

Japanese

Language Subject

Last update

3/5/2018 2:00:45 PM