| Course title | |||||
| 免疫工学 [Immunology] | |||||
| Course category | technology speciality courses,ets. | Requirement | Credit | 1 | |
| Department | Year | 3～4 | Semester | Spring | |
| Course type | Spring | Course code | 023113 | ||
| Instructor(s) | |||||
| 浅野 竜太郎 [ASANO Ryutaro] | |||||
| Facility affiliation | Faculty of Engineering | Office | Email address | ||
| Course description |
|
Antibodies play a central role in acquired immunity and are also used in several research fields from biochemical reagents to molecularly targeted drugs. Students will learn about structure, function, and diversity of immune molecules mainly antibodies, and also learn about their engineering application. |
| Expected Learning |
| Students can learn why antibodies have been widely used from their structure and function, what is the necessary requirement for their application as drugs, and how to design their desired structures. |
| Course schedule |
|
Lecture 1: Basic immunity - acquisition immunity and antibody - Lecture 2: Immune response, and structure and diversity of immune molecules Lecture 3: Screening and preparation of antibodies Lecture 4: Measurements based on antibodies Lecture 5: Intermediate examination Lecture 6: Antibody engineering - humanized antibody, catalytic antibody - Lecture 7: Immunoengineering - chimeric antigen receptor, modified cytokine - Lecture 8: Fragment antibodies and antibody-like molecules Lecture 9: Conjugated antibody and antibody fusion Lecture 10: Development of bispecific antibodies Lecture 11: Development of next-generation cancer therapeutic antibodies Lecture 12: Affinity maturation of antibody Lecture 13: Biosimilar Lecture 14: Development of biologicals - patent, manufacturing, clinical trial - Lecture 15: Final examination |
| Prerequisites |
| none |
| Required Text(s) and Materials |
| none |
| References |
| Biochemistry (Stryer) SEVENTH EDITION |
| Assessment/Grading |
| Attendance (50%) + Intermediate / Final examination (50%) |
| Message from instructor(s) |
| none |
| Course keywords |
| Immunity, Antibody, Diversity, Antibody engineering, Phage display |
| Office hours |
| Remarks 1 |
| Remarks 2 |
| Related URL |
| Lecture Language |
| Japanese |
| Language Subject |
| English |
| Last update |
| 3/26/2018 1:56:12 PM |