| Course title | |||||
| 生物制御科学特論Ⅲ [Special Lecture on Bioregulation and Biointeraction Ⅲ] | |||||
| Course category | common courses | Requirement | Credit | 1 | |
| Department | Year | 1～ | Semester | Spring | |
| Course type | Spring | Course code | 05MC5403 | ||
| Instructor(s) | |||||
| 五十嵐 雅之, 夏目 雅裕 [NATSUME Masahiro] | |||||
| Facility affiliation | Graduate School of Agriculture | Office | Email address | ||
| Course description |
| How to make medicine mainly on natural products derived from microorganisms, especially antibiotics of the research and development. Many agricultural fields such as applied microbiology, fermentation, natural product chemistry, antibiotics, microbial chemistry etc. occupy an important position for natural drug discovery. I would like to introduce the importance as an integrated field. |
| Expected Learning |
|
It can be understood as integrated science such as applied microbiology, fermentation, natural product chemistry, microbial genetics etc. Understanding of the problem drug resistance from the point of view, such as public health and the world economy. Understand the methodology of natural product discovery and development. |
| Course schedule |
|
In Japan, there is accumulation of natural product fermentation technology based on brewing, amino acid fermentation. Natural products discovered and developed in Japan have created many medicines used in the world. Natural products occupy an important position as chemotherapy such as infectious diseases and cancer, as medicine for hyperlipidemia and organ transplantation. Regarding antibiotics supporting today's chemotherapy, I will introduce how drug discovery research from microbial hunt to optimization how to create medicine is like. In recent years, the problem of drug resistance has been caught as a major marvel for global public health and the world economy. As an example of ongoing efforts of natural drug discovery, I will also introduce development research on antibiotics effective for extensively drug-resistant tuberculosis and multi-drug-resistant Gram-negative bacteria. 1. Introduction- Drug Discovery from Natural Products 2. What are antibiotics Position of antibiotics History and outline of antibiotic discovery Drug resistance 3. Search for antibiotics Isolation and identification of antibiotic-producing bacteria Screening Extraction and purification of antibiotics Identification 4. Bioactivity of antibiotics Antibacterial spectrum and minimum inhibitory concentration Mechanism of action of antibiotics Selective toxicity and drug resistance 5. Discovery and development of antibacterial antibiotics Recent research as an example |
| Prerequisites |
| Required Text(s) and Materials |
| References |
| Assessment/Grading |
| Test and report + α |
| Message from instructor(s) |
| I will also talk about research on natural-products screening for the development of antimicrobial agents currently underway at the Institute of Microbiological Chemistry. Please think as practicing subjects studied at the university. |
| Course keywords |
| Microorganisms, Streptomyces, bioactive substance, antibiotics, drug resistance (AMR), screening, drug discovery |
| Office hours |
| Remarks 1 |
| Remarks 2 |
| Related URL |
| http://www.bikaken.or.jp |
| Lecture Language |
| Japanese |
| Language Subject |
| Last update |
| 3/28/2018 4:13:34 PM |