| Course title | |||||
| 動物育種繁殖学特論 [Advanced Animal Breeding and Reproduction Science] | |||||
| Course category | Requirement | Credit | 0.5 | ||
| Department | Year | ～ | Semester | Spring | |
| Course type | Spring | Course code | 96123 | ||
| Instructor(s) | |||||
| 松本 浩道（宇） [MATSUMOTO Hiromichi] | |||||
| Facility affiliation | United Graduate School Agricultural Science | Office | Email address | ||
| Course description |
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“Reproductive Technology in Mammals” It is general knowledge that the reproductive characteristics in eutherian mammals, including humans, are bisexual reproduction, in-vivo fertilization, viviparity and lactation. However, recent advancement on reproductive technologies in mammals, especially in eutherian mammals, has been drastic as everybody knows on TV and in newspaper articles. We would like to introduce the advanced reproductive technologies in mammals and to discuss the problems of technology and safety. This class is divided into two halves. In the first half, I explain reproductive phenomenon and new technologies during preimplantation period. In the last half, I have a lecture related with some phenomenon and new technologies during implantation and periimplantation period. In the first half of the class: “Reproductive Technology in Mammals” After the basic knowledge on mammalian reproduction is briefly given, the advanced reproductive technologies, e.g. in vitro fertilization, embryo transfer, intracytoplasmic sperm injection, nuclear transfer and production of transgenic animals etc., are introduced. Safety and risk of the advanced reproductive technologies are also explained because some advanced reproductive technologies are using for treatments of infertile human patients as “Assisted Reproductive Technologies, ART” in the world. Although importance of cytogenetical safety in embryos derived by ART is well recognized, evaluation and investigation for risk in the ART are insufficient. It has been reported cytogenetical normality in mammalian embryos, including humans, produced by various advanced reproductive techniques. In the last half of the class: “Successful Implantation and Pregnancy” Implantation involves an intricate discourse between the embryo and uterus, and is a gateway to further embryonic development. Synchronizing embryonic development until the blastocyst stage with the uterine differentiation that takes place to produce the receptive state is crucial to successful implantation and therefore to pregnancy outcome. Although implantation involves the interplay of numerous signaling molecules, the hierarchical instructions that coordinate the embryo?uterine dialogue are not well understood. This lecture highlights our knowledge about the molecular development of preimplantation, implantation, and the future challenges of the field. A better understanding of periimplantation biology could alleviate female infertility and help to develop novel contraceptives. |
| Expected Learning |
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In the first half of the class: “Reproductive Technology in Mammals” 1. Understanding of the developmental biology in mammals 2. Understanding of the in vitro fertilization and preimplantation development 3. Consideration for the reproductive technology and its clinical application In the last half of the class: “Successful Implantation and Pregnancy” 1. Understanding of the molecular mechanisms on embryonic development at periimplantation period 2. Understanding of the molecular mechanisms on uterine receptivity at periimplantation period 3. Consideration for the interaction between embryo and uterus during implantation |
| Course schedule |
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In the first half of the class: “Reproductive Technology in Mammals” 1. Summary of the developmental biology in mammals 2. In vitro fertilization and preimplantation development 3. Reproductive technology In the last half of the class: “Successful Implantation and Pregnancy” 1. Molecular mechanisms on embryonic development at periimplantation period 2. Molecular mechanisms on uterine receptivity at periimplantation period 3. Interaction between embryo and uterus during implantation |
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| Message from instructor(s) |
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I will be concerned about detailed explanation. If you have any questions, please do not hesitate to contact with me. |
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| Last update |
| 3/23/2018 5:11:07 PM |