| Course title | |||||
| 植物制御科学特論 [Advanced Plant Regulation Science] | |||||
| Course category | Requirement | Credit | 0.5 | ||
| Department | Year | ～ | Semester | Spring | |
| Course type | Spring | Course code | 96134 | ||
| Instructor(s) | |||||
| 福原 敏行 [FUKUHARA Toshiyuki] | |||||
| Facility affiliation | Faculty of Agriculture | Office | 8-212 | Email address | |
| Course description |
|
“Molecular mechanisms of defense against viruses and transposons by RNA silencing in plants” RNA silencing (RNA interference) is a well-conserved mechanism for gene regulation by small RNAs and defense mechanism against nucleic acid parasites, such as viruses and transposons (transposable elements), in eukaryotes. Molecular mechanisms of gene regulation and defense against viruses and transposons by RNA silencing (small RNAs) in plants will be discussed. |
| Expected Learning |
| Understanding of the molecular mechanism of RNA silencing in plants. Understanding how plants defense against viruses by RNA silencing. |
| Course schedule |
|
1) Discoveries of PTGS and RNAi: Discoveries of post-transcriptional gene silencing (PTGS) from plants in 1990 and RNA interference (RNAi) from animals in 1998 will be lectured. 2) Defense against virus infection by RNA silencing: RNA silencing (RNA interference) functions as a defense mechanism against viruses, but most plant viruses contain a suppressor protein against host RNA silencing. Interaction between host defense mechanisms (RNA silencing) and virus suppressor proteins will be lectured. 3) Suppression of movement of transposons by DNA methylation: Transposons can move within a host genome to induce a serious mutation. Host plants have a mechanism to suppress the mobility of transposons by RNA silencing. Mechanisms of DNA methylation by small RNAs (siRNAs) will be lectured. 4) Small RNAs (micro RNAs, miRNAs) that regulate gene expression: Micro RNAs (miRNAs) regulate expressions of important genes, such as genes encoding transcription factors. Regulation mechanisms of gene expression by miRNAs will be lectured. |
| Prerequisites |
| Required Text(s) and Materials |
| References |
| Assessment/Grading |
| Message from instructor(s) |
| RNA silencing (RNA interference) mechanisms in plants, especially defense mechanisms against viruses and gene regulation mechanisms by small RNAs, will be discussed. |
| Course keywords |
| RNA, RNA interference, virus |
| Office hours |
| 8:30 - 17:00 |
| Remarks 1 |
| Remarks 2 |
| Related URL |
| http://www.tuat.ac.jp/~mcb/ |
| Lecture Language |
| Japanese |
| Language Subject |
| English |
| Last update |
| 3/20/2018 5:50:09 PM |