Course title
蛋白学   [Proteomics]
Course category		Requirement		Credit	2
Department		Year	3～	Semester	3rd
Course type	3rd	Course code	01BN3138
Instructor(s)
殿塚 隆史, 野村 義宏, 西河 淳   [TONOZUKA Takashi, NOMURA Yoshihiro, NISHIKAWA Atsushi]
Facility affiliation	Faculty of Agriculture	Office		Email address

Course description

[Course synopsis] Organisms are composed of molecules that are specifically found in the organisms. This lecture covers structures and types of proteins, which are typical macromolecules in the organisms, and glycans and lipids, which are macromolecules highly related to the proteins. The lecture also covers the physiological functions, analytical methods, and some applications using these macromolecules. [Course objective] This course is a common department subject, and provides topics based on biochemistry.

Expected Learning

- Understanding the structures and types of glycans, and also understanding the physiological functions, roles, and their relations to diseases. - Understanding the chemistry and analytical methods of protein structures, and also understanding the protein folding and its physiological roles. - Understanding the major components and physiological functions of cell membranes and extracellular matrices, which are important for learning of the mechanism of mammalian cells Corresponding criteria in the Diploma Policy: (B) Please refer to the curriculum map at the following URL: https://www.tuat.ac.jp/campuslife_career/campuslife/policy/

Course schedule

Lectures 1 - 5: Atsushi Nishikawa 1) What “glycans” is: basics, including history of the research, of structures, types, and complex carbohydrates 2) Biosynthesis of glycoproteins, and diseases related to the glycoproteins 3) Lectins 4) Physiological roles of glycans in glycoproteins 5) Recent topics of glycans: infectious diseases, medicines, diagnostic markers and more. Lectures 6 - 10: Takashi Tonozuka 6) Chemistry of protein structures and folding 7) Some examples of protein folds 8) Prediction and databases of protein structures 9) Mechanism for supporting the protein folding 10) Methods for protein structure determination Lectures 11-15: Yoshihiro Nomura 11) Introduction of lipids: classification and metabolism 12) Cell membrane and membrane permeation 13) Introduction of extracellular matrices 14) Function of collagens 15) Inherited diseases

Prerequisites

Students need to preview and review for an amount of time as indicated in the student guidelines of TUAT, in addition to the attendance of lecture.

Required Text(s) and Materials

Handouts are provided if needed.

References

McKee Biochemistry, Essential cell biology, etc.

Assessment/Grading

Performance in lecture (including mini-tests) (30%) and assignment report or examination (70%)

Message from instructor(s)

We hope that this lecture will help you on your research in the future.

Course keywords

protein, glycan, extracellular matrix

Office hours

Please contact by e-mail.

Remarks 1

Remarks 2

Related URL

Lecture Language

Japanese

Language Subject

Last update

1/31/2020 10:02:12 AM