| Course title | |||||
| 有機合成化学 [Synthetic Organic Chemistry] | |||||
| Course category | Requirement | Credit | 2 | ||
| Department | Year | 3～ | Semester | 3rd | |
| Course type | 3rd | Course code | 01BN3139 | ||
| Instructor(s) | |||||
| 千葉 一裕 [CHIBA Kazuhiro] | |||||
| Facility affiliation | Center for Infectious Disease Epidemiology and Prevention Research | Office | Email address | ||
| Course description |
| The lecture is held to understand fundamental organic synthesis of biological materials such as plant and insect hormones. |
| Expected Learning |
|
To understand the basic idea about the design of the organic compound synthesis To have a basic knowledge of the carbon-carbon bond formation, functional group transformation reactions To suggest a possible synthesis method on how to synthesize organic compounds To understand the basics for stereoselective synthesis reaction To have a basic understanding of the separation and purification process of organic compounds Viewpoint of diploma policy in this subject: You will learn a wide range of knowledge and culture that will serve as the foundation for addressing applied biological sciences and related domain issues, and acquire flexible thinking skills. In order to elucidate the biological phenomena and interactions among living organisms and their coexistence patterns, and to contribute to the sustainable development of humanity, the systematics of specialized fields from the basics to the leading edge of applied biological sciences and related sciences learn. |
| Course schedule |
|
#1, #2: The significance of organic synthesis Methods of organic synthesis, key points on the experimental procedure, the carbon skeleton formation of the design, use of functional group transformation method, such as the role of the protective group It will be given with examples. #3, #4, #5: Chemical synthesis of the plant hormone We will discuss on the plant hormone, and the methods of chemical synthesis that have been achieved so far,. #6, #7,#8: Chemical synthesis of insect pheromones Based on the insect pheromones, we will discuss the methods of chemical synthesis and the applications. In particular, we will discuss the elucidation of absolute configuration and stereoselective chemical synthesis in detail. #9, #10, #11: Chemical synthesis of insect hormone Based on the insect hormones, chemical synthesis methods and the application will be introduced. #13: Chemical synthesis using microorganisms We will discuss the synthesis of biologically active substances using, for example, yeast reduction method, utilizing the enzyme reaction, and chemical synthesis of peptide biomolecules. We will discuss efficient chemical synthesis of peptide-related substance. #14: Chemical synthesis of agricultural chemicals and pharmaceuticals For searching the synthesis of new pesticides and pharmaceuticals, it will be explained the process leading to the methods. #15: Summary and examination. |
| Prerequisites |
| Organic Chemistry 1, Organic Chemistry 2, it is desirable to have to take the organic chemistry 3. |
| Required Text(s) and Materials |
| Course conditions, related subjects (information for preparing and reviewing, required study time ) is "based on the standard number of hours of the university". |
| References |
|
「最新有機合成法: 設計と戦略」G.S.Zweifel, M.H.Nantz, P. Somfai, 化学同人 「天然有機化合物の全合成:独創的なものづくりの反応と戦略 (CSJカレントレビュー)」化学同人 「有機合成化学 最先端の研究例から学ぶ合成戦略と反応機構 (KS化学専門書)」東郷 秀雄 講談社 「生物活性物質の化学-有機合成の考え方を学ぶ」 森謙治著 化学同人 「生物活性天然物の化学合成 生体機能分子をどうつくるか」 森謙治著 裳華房 |
| Assessment/Grading |
| Evaluated by the examination at the end of the lecture. |
| Message from instructor(s) |
| After learning the basics of organic chemistry, studying organic synthetic chemistry will allow you to systematically understand what you have learned so far. In addition, organic synthetic chemistry is very important in learning how to look for things to explore the reactivity, interaction, and mechanism of activity expression of molecules. For everyone who conducts research in various fields from now on, I would like to make it an opportunity to acquire great research driving force. |
| Course keywords |
| Biologically active natural products chemistry, organic chemistry, synthetic organic chemistry, physiologically active substances |
| Office hours |
| It will be announced during the class. |
| Remarks 1 |
| Remarks 2 |
| Related URL |
| Lecture Language |
| Japanese |
| Language Subject |
| Last update |
| 3/30/2019 6:35:04 PM |