Course title
生命有機化学Ⅰ   [Bioorganic Chemistry Ⅰ]
Course category	technology speciality courses	Requirement		Credit	2
Department		Year	1～4	Semester	3rd
Course type	3rd	Course code	021111
Instructor(s)
櫻井 香里   [SAKURAI Kaori]
Facility affiliation	Faculty of Engineering	Office		Email address

Course description

In Organic Chemistry in Life Science I course, you will learn about fundamental concepts to understand structure and reactivity of organic molecules and their application to synthesis. This course aims to understand reactions of alkenes and alkynes and their application to multistep synthesis of various organic compounds. In this course, basic concepts of stereoisomers, hybridization, resonance structures, acids and bases, nucleophiles and electrophiles, carbon-carbon multiple bonds are reviewed and structures and reactions of alkenes and alkynes, which are major functional groups of organic compounds and their application to multistep synthesis are addressed. In each lecture, home work is assigned which is related to the contents of the lecture. Through this course, you will learn about the molecular representation of organic molecules and the electron arrow pushing to understand the reaction.

Expected Learning

1) Understand nucleophilic substitution reactions and elimination reactions as fundamental organic reactions. 2) Understand the reactions of alkenes and their application to multistep organic synthesis. 3) Understand the reactions of alkynes and their application to multistep organic synthesis. This subject corresponds to the viewpoint A of the diploma policy.

Course schedule

1. Alkyl halides: structure and synthesis (Textbook Chapter 6) You will learn about the structure, properties, and synthesis of alkyl halides. 2. Nucleophilic substitution reactions of alkyl halides 1 (Textbook Chapter 6) You will learn about SN2 reactions of alkyl halides. 3. Nucleophilic substitution reactions of alkyl halides 2 (Textbook Chapter 6) You will learn about SN1 reactions of alkyl halides. 4. Elimination reactions of alkyl halides 1 (Textbook Chapter 6) You will learn about E2 reactions of alkyl halides. 5. Elimination reactions of alkyl halides 2 (Textbook Chapter 6) You will learn about E1 reactions of alkyl halides. 6. Alkenes: structure and synthesis 1 (Textbook Chapter 7) You will learn about stability of alkenes and cycloalkenes, synthesis of alkenes by dehydrohalogenation. 7. Alkenes: structure and synthesis 2 (Textbook Chapter 7) You will learn about stereospecific E2 reactions and multistep synthesis of alkenes. 8. Exam (1~7) 9. Reactions of alkenes 1 (Textbook Chapter 8) You will learn about electrophilic addition reactions of alkenes (addition of hydrogen halides, addition of water). 10. Reactions of alkenes 2 (Textbook Chapter 8) You will learn about electrophilic addition reactions of alkenes (hydroboration, halogenation, hydrogenation). 11. Reactions of alkenes 3 (Textbook Chapter 8) You will learn about epoxidation of alkenes, epoxide ring opening, oxidative cleavage of alkenes. 12. Reactions of alkynes 1 (Textbook Chapter9) You will learn about synthesis of alkynes using acetylides and synthesis of alkynes by elimination reactions. 13. Reactions of alkynes 2 (Textbook Chapter 9) You will learn about addition reactions of alkynes. 14. Reactions of alkynes 3 (Textbook Chapter 9) You will learn about oxidation reactions of alkynes. 15. Exam (9~14)

Prerequisites

This lecture is a series of chemistry courses, following "Basic Chemistry" and continuing to "Organic Chemistry in Life Science II". You are encouraged to take those lectures for the “Organic Chemistry in Life Science I”.

Required Text(s) and Materials

Wade Organic Chemistry (Maruzen).

References

Wade Organic Chemistry Solution Manual (Maruzen)

Assessment/Grading

Evaluation will be made based on the results of the report (20%) and the final exam (80%).

Message from instructor(s)

Understanding of the structure and reactivity of organic molecules will be key to organic synthesis of drugs and functional materials as well as understanding in biomolecular reactions. You will learn the mechanism and design strategy with molecular level. Approaches to the problem sets in the homework will be discussed in the following class. Please review carefully and use these occasions for understanding the contents in the course.

Course keywords

alkenes, alkynes, nucleophilic substitution reactions, elimination reactions, stereospecific reactions, multistep synthesis

Office hours

Remarks 1

Remarks 2

Related URL

Lecture Language

Japanese

Language Subject

Last update

3/6/2019 2:58:25 PM