Course title
生命物理化学Ⅰ   [Biophysical Chemistry Ⅰ]
Course category technology speciality courses,ets.  Requirement   Credit 2 
Department   Year 2～4  Semester 1st 
Course type 1st  Course code 022104
Instructor(s)
中村 暢文   [NAKAMURA Nobufumi]
Facility affiliation Faculty of Engineering Office   Email address

Course description
Students will learn about physical chemistry becoming basic in biotechnology in this class. This class covers chemical equilibrium and electron transfer based on the thermodynamics and spectroscopies based on the quantum mechanics.
Expected Learning
Students who successfully complete this class will be able to:
1) Discuss chemical equilibrium, phenomena responsible for life, and biopolymer based on thermodynamics.
2) Recognize basic quantum mechanics and understand spectroscopies which is used for observation of biomolecules.

This subject corresponds to the viewpoint A of the diploma policy.
Course schedule
Week 1: Orientation of this class. Reviewing thermodynamics.
Week 2: Phase equilibria 1 (Chapter 3)
Learning phase, phase transition, and phase diagram.
Week 3: Phase equilibria 2 (Chapter 3)
Learning ideal solutions, Raoult’s law, ideal-dilute solutions, and Henry’s
law.
Week 4: Phase equilibria 3 (Chapter 3)
Understanding phase transitions in biopolymers and of biological membranes
and chemical potential.
Week 5: Phase equilibria 4 (Chapter 3)
Understanding the real solutions, activity, and colligative properties.
Week 6: Chemical equilibrium 1 (Chapter 4)
Learning the reaction Gibbs energy, chemical equilibrium, the equilibrium
constant.
Week 7: Chemical equilibrium 2 (Chapter 4)
Understanding Le Chatelier’s principle and bioenergetics.
Week 8: Chemical equilibrium 3 (Chapter 4)
Understanding acids and bases, proton transfer equilibria, and buffer
solutions.
Week 9: Midterm examination
Week 10: Some comments about the midterm examination
Week 11: Thermodynamics of ion and electron transport 1 (Chapter 5)
Understanding transport of ions across biological membranes and redox
reactions.
Week 12: Thermodynamics of ion and electron transport 2 (Chapter 5)
Understanding standard potentials and electron transfer in bioenergetics.
Week 13: Biochemical spectroscopy 1 (Chapter 12)
Reviewing quantum mechanics. Learning vibrational spectroscopies
(IR and Raman).
Week 14: Biochemical spectroscopy 2 (Chapter 12)
Learning ultraviolet and visible absorption spectroscopy and fluorescence
spectroscopy.
Week 15: Final examination
Prerequisites
Students entering this class are assumed to have had “Thermodynamics” and “Basic quantum mechanics”. This class leads to “Biophysical chemistry II” and “Bio-related electronics”.
In addition to 30 hours that students spend in the class, students are recommended to prepare for and revise the lectures, spending the standard amount of time as specified by the University by reviewing the exercises to be done in each lesson and by solving the problems at the end of the text.
Required Text(s) and Materials
Peter Atkins and Julio de Paula, Physical chemistry for the life sciences 2nd Edition, Oxford University Press 2011.
References
1) Donald A. McQuarrie and John D. Simon, Physical chemistry -a molecular approach-, University Science Books 1997.
2) Peter Atkins and Julio de Paula, Atkins' Physical chemistry 9th Edition, Oxford University Press 2010.
3) Hans Kuhn and Horst-Dieter Feorsterling, Principles of physical chemistry, Wiley 1999.
Assessment/Grading
Grades will be assigned based on students' performance on examination, quizzes, and reports. Midterm examination; 35%, final examination; 55%, and quizzes and reports; 10%.
Message from instructor(s)
Let's learn about principles of life and physicochemical methods to observe life with pleasure!
Course keywords
Thermodynamics, Quantum mechanics, Chemical equilibrium, Electron transfer, Bioenergetics, Spectroscopy
Office hours
16:00-17:00 Friday; Room 307, 3rd floor, 12th Building, Koganei Campus
Remarks 1
Remarks 2
Related URL
Lecture Language
Japanese
Language Subject
English
Last update
3/4/2019 6:59:56 PM