Course title
生命有機化学Ⅱ   [Bioorganic Chemistry Ⅱ]
Course category	technology speciality courses,ets.	Requirement		Credit	2
Department		Year	2～4	Semester	1st
Course type	1st	Course code	022105
Instructor(s)
長澤 和夫   [NAGASAWA Kazuo]
Facility affiliation	Graduate School of Engineering	Office		Email address

Course description

In the Organic Chemistry in Life Science II, you will learn the characters and reactivities of functional groups in organic compounds. Since the characters of functional groups in organic compound are closely related to the reactivity of the organic compounds, then you will understand the variety of reactions occurring in vivo throughout the course, which is categorized as a basic subject of life science. In this course, properties and reactivity of alcohols, ethers and carboxylic acids are addressed. In addition, you will learn stability and reactivity of aromatic compounds from the viewpoint of aromaticity. In each lecture, quiz-type home work is assigned which is related to the contents of the lecture. Through this course, you will learn about the electron arrows to understand the reaction.

Expected Learning

1) Understand the properties of alcohols, ethers, carboxylic acids and explain their reactivity using electron arrows. 2) Aromaticity and its reactivity can be explained by using electron arrows. This subject corresponds to the viewpoint A of the diploma policy.

Course schedule

1. Synthesis and Structure of Alcohol 1 (Textbook Chapter 10) You will learn about the structure and properties of alcohols, and properties of phenol. 2. Synthesis and Structure of Alcohol 2 (Textbook Chapter 10) You will learn about Grignard reaction and reduction of carbonyl group. 3. Reaction of alcohol 1 (Textbook Chapter 11) You will learn about oxidation and reduction of alcohols. 4. Reaction of alcohol 2 (Textbook Chapter 11) You will learn about halogenation, dehydration and esterification of alcohols. 5. Ether, Epoxide 1 (Textbook Chapter 14) You will learn about the synthesis and reaction of ether. 6. Epoxide 2 (Textbook Chapter 14) You will learn about synthesis and reaction of epoxide. 7. Aromatic compound 1 (Chapter 16 of the textbook) You will learn about the structure and properties of aromatic compounds, and aromaticity (Huckel's rule). 8. Aromatic compound 2 (Chapter 16 of the textbook) You will learn about heteroaromatic compounds. 9. Reaction of aromatic compound 1 (Textbook Chapter 17) You will learn about electrophilic substitution reactions of aromatic compounds (halogenation, nitration, sulfonation etc.). 10. Reaction of aromatic compound 2 (Textbook Chapter 17) You will learn about Friedel-Crafts reaction, nucleophilic substitution reaction of aromatic compounds. 11. Carboxylic acid 1 (Textbook Chapter 20) You will learn about the properties and synthesis of carboxylic acids. 12. Carboxylic Acid 2 (Textbook Chapter 20) You will learn about the reaction of carboxylic acid (Fischer esterification, amide synthesis, reduction). 13. Carboxylic acid derivatives 1 (textbook chapter 21) You will learn about the carboxylic acid derivatives and their conversion reactions. 14. Carboxylic acid derivatives 2 (textbook Chapter 21) You will learn about the reaction of carboxylic acid derivatives (hydrolysis, reduction, reaction with metal reagents). 15. Term-end exam

Prerequisites

This lecture is a basic course of chemistry, following "Basic Chemistry" and "Organic Chemistry in Life Science I". In order to take the course of “Medicinal Chemistry ", you are encouraged to take this lecture.

Required Text(s) and Materials

Wade Organic Chemistry (Maruzen).

References

Bruce Organic Chemistry (Kagaku-Dojin), McMurry Organic Chemistry (Tokyo Kagaku-Dojin) and other texts will be introduced in the course.

Assessment/Grading

Evaluation will be made based on the results of the report (20%) and the final exam (80%).

Message from instructor(s)

To understand the reaction and properties of organic chemistry, understanding electron arrows is very important. I will check and return the submitted home-work with some comments, especially focusing on the electron arrow. Please review carefully and use these occasions for understanding the contents in the course.

Course keywords

functional group in organic compounds, alcohol, ether, carboxylic acid, aromaticity, electron arrow

Office hours

Monday 12-14

Remarks 1

Remarks 2

Related URL

Lecture Language

Japanese

Language Subject

Last update

2/23/2019 1:16:14 PM