Course title
創薬化学特論   [Advanced Agrochemical and Medicinal Chemistry]
Course category	specialized field courses	Requirement		Credit	2
Department		Year	1～	Semester	1st
Course type	1st	Course code	05MC5419
Instructor(s)
夏目 雅裕, 平井 憲次, 助川 正之   [NATSUME Masahiro, HIRAI Kenji, SUKEKAWA Masayuki]
Facility affiliation	Faculty of Agriculture	Office	2-403	Email address

Course description

In modern agriculture, chemical pesticides are indispensable agricultural materials for protecting crops from damage by pests such as pests and weeds, and ensuring stable food production. Development research from discovery to registration of new pesticides involves different fields such as "chemistry" related to the creation of new compounds, "biology" responsible for various biological evaluation tests, and "toxicology" to evaluate the safety of compounds. The researcher of this group works closely with each other to promote research, and this leads to the creation of a new drug. In this lecture, we will focus on lead compound creation research, which is an early stage of the creation of new agricultural chemicals.In particular, we will create random synthetic lead compounds, create mimic synthetic lead compounds, and develop lead compounds using a biorational approach. The creation of a lead compound using computer chemistry and the like will be explained with examples of the synthesis of specific compounds and photos of biological evaluation tests (greenhouse test, field test, etc.).

Expected Learning

1. To understand basic process of synthetic pesticide development. 2. To understand recent methods for developing new pesticides. Corresponding criteria in the Diploma policy: See the curriculum maps. https://www.tuat.ac.jp/campuslife_career/campuslife/policy/

Course schedule

Dr. Sukekawa 1. Overview of new pesticide development 2. Development of fungicide cyflufenamide 3. Structure-activity relationship concept 4. Quantitative structure-activity relationship 5. Theoretical chemical calculations for drug discovery 6. Drug-receptor interaction and three-dimensional structure-activity relationship 7. Development and validation of hypotheses 8. Drug-receptor interaction and three-dimensional structure-activity relationship (drug design from target site information) Hirai 1. Introduction to pesticides (usefulness, safety), food production, pesticide market, etc.) 2. Introduction to pesticides (food production, pesticide market, etc.) 3. Drug discovery chemistry in pesticide development 4. Drug Discovery Research Topics-Success and Failure in Development Research (1) Development Research of Pentoxazone Herbicide for Paddy Field 5. Drug discovery research topics-success and failure in development research (2) Development research of pyrazole herbicides (4-HPPD inhibitor, PDS inhibitor, PPO inhibitor) 6. Drug Discovery Research Topics-Success and Failure in Development Research 7. Development trend of pesticides (mainly fluorine-containing pesticides) (3) Development research of pyrazole fungicides (mitochondrial respiratory chain electron transport complex II inhibitors) 8. Conclusion

Prerequisites

In addition to 30 hours that students spend in the class, students are recommended to prepare for and revise the lectures, spending the standard amount of time as specified by the University and using the lecture handouts as well as the references specified below.

Required Text(s) and Materials

The printed material will be distributed.

References

by the demand

Assessment/Grading

Credit will be given on the basis of the the short report in each lecture and essays.

Message from instructor(s)

Course keywords

pesticide, development research, computational chemistry, patent stratay

Office hours

Since it is an intensive lecture by a part-time lecturer, questions related to the lecture contents will be handled after the lecture or by e-mail.

Remarks 1

Remarks 2

Related URL

Lecture Language

Japanese

Language Subject

Last update

1/27/2020 8:48:16 AM