| Course title | |||||
| 動物栄養飼料学特論 [Advanced Animal Nutrition and Feed Science] | |||||
| Course category | Requirement | Credit | 0.5 | ||
| Department | Year | ～ | Semester | 3rd | |
| Course type | 3rd | Course code | 96122 | ||
| Instructor(s) | |||||
| 吉澤 史昭（宇） [YOSHIZAWA Fumiaki] | |||||
| Facility affiliation | United Graduate School Agricultural Science | Office | afjgxte/L1151 | Email address | |
| Course description |
|
“Notable functions of amino acids as biological regulators” Although not widely appreciated, nutritional signals play an important role in controlling physiological functions in mammals. Amino acids serve as precursors in protein synthesis. Apart from being bound as proteins, amino acids also exist in free form in many tissues and plasma and act as important signaling molecules. Branched-chain amino acids (BCAAs) are the most noticed essential amino acids that have non-linear aliphatic sidechains, which include leucine, isoleucine and valine. BCAAs have recently been recognized as having functions other than simple nutrition. The signaling action of BCAAs has been well studied, and the mechanisms are currently under investigation. The purpose of this lecture is to briefly review the current knowledge of how BCAAs act as regulators of protein metabolism, glucose metabolism and body temperature. |
| Expected Learning |
| Understanding of a key role for amino acids as nutritional signals in the regulation of a number of cellular processes. |
| Course schedule |
|
1. Regulation of protein synthesis by BCAAs 1-1. Overview of translation initiation 1-2. Regulation of translation initiation by BCAAs 1-3. Signal transduction pathways required for the stimulation of translation initiation by leucine 2. Hypoglycemic effect of isoleucine 2-1. Effects of isoleucine on glycogen synthesis and glucose oxidation 2-2. Effects of isoleucine on glucose uptake in peripheral tissues and hepatic glucose production 3. Thermoregulatory functions of BCAAs |
| Prerequisites |
| Prerequisite for this lecture is basic knowledge of biochemistry and nutrition. |
| Required Text(s) and Materials |
| Handouts will be provided in class. |
| References |
| To be announced in the lectures. |
| Assessment/Grading |
| Message from instructor(s) |
| As BCAAs serve to regulate the metabolism of major nutrients, similarly to hormone, the value of their use as biological regulators cannot be overestimated. BCAAs are nutrients that should therefore be a focus of investigation as next-generation biological regulators. You will begin to look at amino acids in a different way. |
| Course keywords |
| Office hours |
| Monday-Wednesday 12:00-12:50 |
| Remarks 1 |
| Remarks 2 |
| Related URL |
| Lecture Language |
| Japanese |
| Language Subject |
| Last update |
| 2/26/2019 2:02:32 PM |