Course title
蛋白学   [Proteomics]
Course category		Requirement		Credit	2
Department		Year	3～	Semester	3rd
Course type	3rd	Course code	01BN3138
Instructor(s)
殿塚 隆史, 野村 義宏, 宮田 真路   [TONOZUKA Takashi, NOMURA Yoshihiro, MIYATA Shinji]
Facility affiliation	Faculty of Agriculture	Office	afjgxte/L1151	Email address

Course description

[Course synopsis] Organisms are composed of molecules that are specifically found in the organisms. This lecture covers structures and types of proteins, which are typical macromolecules in the organisms, and glycans and lipids, which are macromolecules highly related to the proteins. The lecture also covers the physiological functions, analytical methods, and some applications using these macromolecules. [Course objective] This course is a common department subject, and provides topics based on biochemistry.

Expected Learning

- Understanding the structures and types of glycans, and also understanding the physiological functions, roles, and their relations to diseases. - Understanding the chemistry and analytical methods of protein structures, and also understanding the protein folding and its physiological roles. - Understanding the major components and physiological functions of cell membranes and extracellular matrices, which are important for learning of the mechanism of mammalian cells Corresponding criteria in the Diploma Policy: (B) Please refer to the curriculum map at the following URL: https://www.tuat.ac.jp/campuslife_career/campuslife/policy/

Course schedule

Lectures 1 - 5: Takashi Tonozuka 1) Chemistry of protein structures and folding 2) Some examples of protein folds 3) Prediction and databases of protein structures 4) Mechanism for supporting the protein folding 5) Methods for protein structure determination Lectures 6 - 10: Yoshihiro Nomura 6) Introduction of lipids: classification and metabolism 7) Cell membrane and membrane permeation 8) Introduction of extracellular matrices 9) Function of collagens 10) Inherited diseases Lectures 11 - 15: Shinji Miyata 11) What “glycans” is: basics, including history of the research, of structures, types, and complex carbohydrates 12) Biosynthesis of glycoproteins, and diseases related to the glycoproteins 13) Lectins 14) Physiological roles of glycans in glycoproteins 15) Recent topics of glycans: infectious diseases, medicines, diagnostic markers and more.

Prerequisites

Students need to preview and review for an amount of time as indicated in the student guidelines of TUAT, in addition to the attendance of lecture.

Required Text(s) and Materials

Handouts are provided if needed.

References

McKee Biochemistry, Essential cell biology, etc.

Assessment/Grading

Performance in lecture (including mini-tests) (30%) and assignment report or examination (70%)

Message from instructor(s)

We hope that this lecture will help you on your research in the future.

Course keywords

protein, glycan, extracellular matrix

Office hours

Please contact by e-mail.

Remarks 1

Remarks 2

Related URL

Lecture Language

Japanese

Language Subject

Last update

8/24/2020 9:58:34 AM