| Course title | |||||
| 生命物理化学Ⅱ [Biophysical Chemistry Ⅱ] | |||||
| Course category | technology speciality courses | Requirement | Credit | 2 | |
| Department | Year | 2～4 | Semester | 3rd | |
| Course type | 3rd | Course code | 022156 | ||
| Instructor(s) | |||||
| 中村 暢文, 一川 尚広 [NAKAMURA Nobufumi, ICHIKAWA Takahiro] | |||||
| Facility affiliation | Faculty of Engineering | Office | afjgxte/L1151 | Email address | |
| Course description |
|
Life phenomena are the accumulation of chemical reactions. This class aims students to understand basics of chemical reactions occurring in vivo, and to learn basic knowledge of analytical methods for these reactions. Additionally, it is intended to understand the methodology to analyze “changes”. In the class, it is important to understand the relationships between molecular structure and their properties. Also students will understand the special “field” formed by polymers which is important to maintain various life actions. Followings are some concrete topics at the class. 1. Interactions between molecules, how and why? 2. Relationships between molecular dynamics and reaction rate 3. Reaction kinetics and rate law It is no meaning to learn equations by rote. Important thing is to understand the meaning of the equations. |
| Expected Learning |
|
To understand life phenomena physicochemically. To understand various reactions occurred accurately in not a diluted solution but a concentrated solution containing polymers and other materials in vivo. This subject corresponds to the viewpoint A of the diploma policy. |
| Course schedule |
|
Characteristics of polymers: Learn the characteristics and nature of polymers working in vivo. Structure of molecules and their interactions: Interactions will be comprehended by some cases of different molecules. Learn relationship between molecular structure and intermolecular interactions. Biopolymers 1: Learn the relationships between higher ordered structure of polymers and specific functions generated from the structure. Biopolymers 2: Learn about entropy and hierarchical polymer structures in solutions. Molecular assembly 1: Learn why molecules assembled freely in aqueous media in spite of the decrease in entropy. Also understand the function of cell membranes (surfactants, emulsions). Molecular assembly 2: Learn a characteristic of surfaces of the aggregated molecules and ions. Chemical kinetics 1: Learn a kinetics, reaction order and elementary process. Chemical kinetics 2: Learn Arrhenius equation and activation energy. Rate equation: Learn the rate determining process and reaction dynamics. Complexed mechanism in biochemistry: Underatanding of enzymatic reactions physicochemically. Learn the electron transfer mechanism in vivo (transfer through membrane, Marcus theory). Fast reaction analysis technology: Learn about stopped flow method, flash photolysis method, pulse radiolysis method, etc. |
| Prerequisites |
|
Take a course in life physical chemistry I in advance. Associated subjects are biochemistry, polymer chemistry, and molecular biology. In addition to 30 hours that students spend in the class, students are recommended to prepare for and revise the lectures, spending the standard amount of time as specified by the University by reviewing the exercises to be done in each lesson and by solving the problems at the end of the text. |
| Required Text(s) and Materials |
| Physical Chemistry for the Life Science 2nd ed. (Oxford University Press, Oxford, UK, 2011) by P. Atkins and J. de Paula |
| References |
| Basic Biophysical Chemistry (Sankyo Shuppan Co.,Ltd.) by K Shirahama et al. |
| Assessment/Grading |
|
Grades will be assigned based on students' performance on examination. Midterm examination; 50%, final examination; 50%. |
| Message from instructor(s) |
|
To understand biological phenomena as molecular level phenomena is very important for biotechnological research. Students should understand it firmly. |
| Course keywords |
| Molecular structure, Physical chemistry, Molecular dynamics, Kinetics, Molecular interaction, Polymer, Molecular assembly |
| Office hours |
| 16:00-17:00 Friday |
| Remarks 1 |
| Nobuhumi Nakamura (Room 307, 3rd floor, 12th Building) |
| Remarks 2 |
| Takahiro Ichikawa (Room 301, 3rd floor, 12th Building) |
| Related URL |
| Lecture Language |
| Japanese |
| Language Subject |
| English |
| Last update |
| 10/1/2020 3:39:59 PM |