Course title
有機化学Ⅲ   [Organic ChemistryⅢ]
Course category	technology speciality courses	Requirement		Credit	2
Department		Year	2～4	Semester	1st
Course type	1st	Course code	022378
Instructor(s)
中野 幸司   [NAKANO Koji]
Facility affiliation	Faculty of Engineering	Office	afjgxte/L1151	Email address

Course description

This course provides basic knowledge and concept in organic chemistry systematically, following Organic Chemistry I and II. The topics covered in this course are “reactions with organometallic compounds”, “radical reactions”, “reactions with carbonyl compounds” and “reactions of aromatic compounds”.

Expected Learning

Understand and explain the reactivity of basic organometallic compounds that are frequently used in organic chemistry. Explain the characteristics of radical reactivity, explain the properties of carbonyl compounds, the substitution reactions and condensation reactions found in these compounds, and the reaction mechanism. A thorough understanding of the properties, reactions, and orientation of aromatic compounds, and the ability to predict reactions. In addition, from the products in these ranges, starting materials that can be used as raw materials for synthesis can be predicted, and the reaction route can be explained. For the curriculum policy perspective of this course, please refer to the curriculum map in the Faculty of Engineering Course Guide.

Course schedule

[1st] "Organometallic compounds" Organic typical metal compounds, cross-coupling reactions, Mizorogi Heck reaction, alkene metathesis (Chapter 12 of textbooks) [2nd] "Reaction of radicals and alkanes" Alkyl halogen compounds, radical stability, radical reactivity, stereochemistry of radical substitution and radical addition, radical substitution of benzylic and allylic hydrogens (textbook chapter 13) [3rd] "Reaction of carboxylic acid and carboxylic acid derivative (1)" Naming of carboxylic acids and carboxylic acid derivatives, structure and physical properties, comparison of reactivity and reactivity, generality of nucleophilic addition-elimination (textbook chapter 16) [4th] "Reaction of carboxylic acid and carboxylic acid derivative (Part 2)" Reaction of acyl chloride, reaction of ester, hydrolysis and transesterification of ester, nucleophilic addition and elimination (textbook Chapter 16) [5th] "Reaction of carboxylic acid and carboxylic acid derivative (3)" Carboxylic acid, amide, nitrile, acid anhydride, dicarboxylic acid (textbook Chapter 16) [6th] Summary "Interim test" Scope of questions: Textbooks Chapter 12, Chapter 13, Chapter 16 [7th] "Reaction of aldehyde and ketone, carboxylic acid derivatives and other reactions, reaction of α, β-unsaturated carbonyl compounds (Part 1)" Aldehyde, ketone nomenclature, carbonyl compound reactivity comparison, Grignard reagent reaction, carbonyl compound and acetylide reaction, cyanide ion reaction, hydride ion reaction, reduction reaction (textbook chapter 17) [8th] Reactions of aldehydes and ketones ・ Carboxylic acid derivatives and other reactions ・ Reactions of α, β-unsaturated carbonyl compounds (Part 2) Reaction with amine, reaction with water, reaction with alcohol, protecting group, Wittig reaction, reaction of a, b-unsaturated carbonyl compound (Chapter 17 of textbook) [9th] "Reaction of α-carbon of carbonyl compounds (1)" Alpha hydrogen acidity, tautomerism, halogenation, HVZ reaction (textbook Chapter 18) [10th] "Reaction of α-carbon of carbonyl compounds (2)" Enolate, alkylation of α-carbon, Michael reaction, addition of aldol (Chapter 18 of textbook) [11th] "Reaction of α-carbon of carbonyl compounds (3)" Claisen condensation, intramolecular condensation, Robinson cyclization, malonate synthesis, acetoacetate synthesis, biological reactions (textbook chapter 18) [12th] "Reaction of benzene and substituted benzene (1)" Nomenclature of benzene derivatives, aromatic electrophilic substitution, halogenation, nitration, sulfonation (Chapter 19 of textbooks) [13] "Reaction of benzene and substituted benzene (2)" Friedel-Crafts reaction, cross-coupling reaction, substituent conversion reaction on benzene ring, polysubstituted benzene (textbook Chapter 19) [14th] "Reaction of benzene and substituted benzene (3)" Substituent effect, orientation, pKa and substituent, synthesis of trisubstituted benzene, synthesis using diazonium salt, aromatic nucleophilic substitution reaction (textbook Chapter 19) [15th] Summary "Final exam" Scope of questions: Textbooks 17-19

Prerequisites

Since it is one of the organic chemistry subjects grouped into specialized basic subjects in the Department of Applied Chemistry, sufficient knowledge about "Organic Chemistry I" and "Organic Chemistry II" is required. In addition to 30 hours of class time, it is necessary to prepare for and review more than the same time.

Required Text(s) and Materials

Bruce Organic Chemistry 7th edition, chemical coterie ISBN978-4-7598-15854-9 and the second volume ISBN978-4-7598-1585-6

References

Files / home work used in lectures can be used in the Moodle system

Assessment/Grading

The grade evaluation in this online class is premised on all attendances, and comprehensively evaluates the attitude to learn, quizzes, report, and online tests. Standard study time set by the our university is required to get the grade. The rate of evaluation is as follows: Normal score: 25%, quizzes and assignment test: 50%, and online test: 25%. Grade will be given according to the following criteria by comprehensive evaluation: S: 90 points or more, A: 80 or more and less than 90 points, B: 70 or more and less than 80 points, C: 60 or more and less than 70 points. The final grade will be made by apportioning with the grade assigned by Prof. Hirano.

Message from instructor(s)

Course keywords

Office hours

One hour after each lecture. Please try to make an appointment (e-mail: k_nakano@cc.tuat.ac.jp; Tel: 042-388-7162) if you are unable to attend the scheduled office hours.

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Lecture Language

Japanese

Language Subject

Last update

5/9/2020 2:22:44 PM