Course title
免疫工学   [Immunology]
Course category technology speciality courses,ets.  Requirement   Credit 1 
Department   Year 34  Semester 1st 
Course type 1st  Course code 023113
Instructor(s)
浅野 竜太郎   [ASANO Ryutaro]
Facility affiliation Faculty of Engineering Office afjgxte/L1151  Email address

Course description
Students will learn about mainly proteins involved in immunity from the basics to engineering application. The aim of this lecture is to understand the structure, function and diversity of proteins involved in immunity especially antibodies, and also to learn how these molecules have been successfully applied as molecular target drugs.
Expected Learning
Students who successfully complete this class will be able to:
1) understand correctly the overview of acquired immunity and the cells and proteins involved in it.
2) understand the structure, function and diversity of antibodies and explain how to obtain them.
3) explain correctly the engineering application examples of protein involved in immunity.
Course schedule
Lecture 1: Basic immunity - acquired immunity and antibody -
Lecture 2: Immune response, and structure and diversity of molecules involved in immunity
Lecture 3: Screening and preparation of antibodies
Lecture 4: Measurements using antibodies
Lecture 5: Midterm examination
Lecture 6: Antibody engineering - humanized antibody, catalytic antibody and so on-
Lecture 7: Immunoengineering - chimeric antigen receptor, modified cytokine and so on-
Lecture 8: Fragment antibodies and antibody-like molecules
Lecture 9: Affinity maturation of antibody
Lecture 10: Antibody conjugate and antibody fusion
Lecture 11: Development of bispecific antibodies
Lecture 12: Development of next-generation cancer therapeutic antibodies
Lecture 13: Biosimilar
Lecture 14: Development of biologicals - patent, manufacturing and clinical trial -
Lecture 15: Final examination
Prerequisites
Because this lecture contains a lot of contents regarding structure and modification of proteins, it is desirable that students take "Protein Science" in advance.
Required Text(s) and Materials
none
References
Biochemistry (Stryer)
Assessment/Grading
Quizzes and reports (30%) + Midterm examination (30%) + Final examination (40%)

In a online class, the students will be evaluated by their performances on class participation (50%) and quizzes and reports (50%).
Message from instructor(s)
Recently, the number of launches of antibody drug is rapidly increasing, and researchers contributing to the development of key technologies were awarded Nobel Prizes. Additionally, medical applications of engineered antibody are rising more and more such as chimera chimeric antigen receptor (CAR) therapy. I would like students to understand the reasons why antibodies have been widely used industrially from the structure and function, and also understand the requirements especially for development them as medical applications.
Course keywords
Antibody, Phage display, Molecular target drug, Antibody drug, Artificial antibody, Chimeric antigen receptor
Office hours
Remarks 1
Remarks 2
Related URL
Lecture Language
Japanese
Language Subject
English
Last update
5/1/2020 1:29:11 PM