| Course title | |||||
| 免疫工学 [Immunology] | |||||
| Course category | technology speciality courses,ets. | Requirement | Credit | 1 | |
| Department | Year | 3～4 | Semester | 1st | |
| Course type | 1st | Course code | 023113 | ||
| Instructor(s) | |||||
| 浅野 竜太郎 [ASANO Ryutaro] | |||||
| Facility affiliation | Faculty of Engineering | Office | afjgxte/L1151 | Email address | |
| Course description |
| Students will learn about mainly proteins involved in immunity from the basics to engineering application. The aim of this lecture is to understand the structure, function and diversity of proteins involved in immunity especially antibodies, and also to learn how these molecules have been successfully applied as molecular target drugs. |
| Expected Learning |
|
Students who successfully complete this class will be able to: 1) understand correctly the overview of acquired immunity and the cells and proteins involved in it. 2) understand the structure, function and diversity of antibodies and explain how to obtain them. 3) explain correctly the engineering application examples of protein involved in immunity. |
| Course schedule |
|
Lecture 1: Basic immunity - acquired immunity and antibody - Lecture 2: Immune response, and structure and diversity of molecules involved in immunity Lecture 3: Screening and preparation of antibodies Lecture 4: Measurements using antibodies Lecture 5: Midterm examination Lecture 6: Antibody engineering - humanized antibody, catalytic antibody and so on- Lecture 7: Immunoengineering - chimeric antigen receptor, modified cytokine and so on- Lecture 8: Fragment antibodies and antibody-like molecules Lecture 9: Affinity maturation of antibody Lecture 10: Antibody conjugate and antibody fusion Lecture 11: Development of bispecific antibodies Lecture 12: Development of next-generation cancer therapeutic antibodies Lecture 13: Biosimilar Lecture 14: Development of biologicals - patent, manufacturing and clinical trial - Lecture 15: Final examination |
| Prerequisites |
| Because this lecture contains a lot of contents regarding structure and modification of proteins, it is desirable that students take "Protein Science" in advance. |
| Required Text(s) and Materials |
| none |
| References |
| Biochemistry (Stryer) |
| Assessment/Grading |
|
Quizzes and reports (30%) + Midterm examination (30%) + Final examination (40%) In a online class, the students will be evaluated by their performances on class participation (50%) and quizzes and reports (50%). |
| Message from instructor(s) |
| Recently, the number of launches of antibody drug is rapidly increasing, and researchers contributing to the development of key technologies were awarded Nobel Prizes. Additionally, medical applications of engineered antibody are rising more and more such as chimera chimeric antigen receptor (CAR) therapy. I would like students to understand the reasons why antibodies have been widely used industrially from the structure and function, and also understand the requirements especially for development them as medical applications. |
| Course keywords |
| Antibody, Phage display, Molecular target drug, Antibody drug, Artificial antibody, Chimeric antigen receptor |
| Office hours |
| Remarks 1 |
| Remarks 2 |
| Related URL |
| Lecture Language |
| Japanese |
| Language Subject |
| English |
| Last update |
| 5/1/2020 1:29:11 PM |