Course title
先端ゲノム情報解析工学特論   [Advanced Lectures on Genome Analysis Engineering]
Course category courses for doctoral programs  Requirement   Credit 2 
Department   Year   Semester 1st 
Course type 1st  Course code 1080114
Instructor(s)
養王田 正文, 篠原 恭介   [YOHDA Masafumi, SHINOHARA Kyosuke]
Facility affiliation Faculty of Engineering Office afjgxte/L1151  Email address

Course description
Current advances and foundations of life sciences are built and supported by genome analysis. Advances in genome analysis are supported by various technological developments, and those developing new technologies are leading the way. In the first half of this lecture, we introduce the history and current state of genome analysis, and explain in detail the progress and current situation of analysis technology. In addition, we introduce mass spectrometry and genetic modification technology used for identification of expressed proteins and analysis of post-translational modifications, as a technique using genomic information.
Expected Learning
Learn the basic knowledge on genome analysis and understand the technology that becomes the basis. In addition, we will master the fundamentals of mass spectrometry technology and genetic modification technology.
Course schedule
July 13th and 14th 3-5 Period Dr.Yohda
History of Human Genome Analysis: We will explain the history and background of human genome analysis.
Advances in genome analysis technology: Explain the progress of technologies realizing genome analysis.
Current status of genome analysis: We introduce the current state of genome analysis and discuss future direction.
Advances in DNA sequencing technology: Explain the development of automatic sequencer and capillary array DNA sequencer. In case
Ultrafast DNA sequencing technology: technology of next generation DNA sequencer We will explain the third generation DNA sequencer.
Future of DNA sequencing: We introduce trend of development of 3rd generation DNA sequencer such as 1 molecule sequencer.

July 15th 2-6 Period Dr. Sinohara
[1] Gene targeting by homologous recombination [2] We introduce knockout mouse production technology and transgenic mouse production technology by recently developed genome editing technology such as ZINC FINGER, TALEN, Crisper-Cas, etc. This will acquire the historical background of the development of development engineering and basic knowledge on the latest technology.

July 16th 3-5 Period Dr. Noguchi
Lecture on mass spectrometry method used for identification of proteins expressed based on genomic information and analysis of posttranslational modification. The first half describes the principle of ionization and mass separation of proteins and peptides, and the latter part introduces the protein identification by peptide mass fingerprinting etc.
Prerequisites
Required Text(s) and Materials
References
Assessment/Grading
Report 100%
Message from instructor(s)
Course keywords
Office hours
Monday 10:30 - 12:00
Remarks 1
Remarks 2
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Lecture Language
Japanese
Language Subject
Last update
2/4/2020 2:24:30 PM