| Course title | |||||
| 免疫学・抗体工学 [Introduction to Immunology / Antibody Engineering] | |||||
| Course category | technology speciality courses | Requirement | Credit | 1 | |
| Department | Year | 3～4 | Semester | 1st | |
| Course type | 1st | Course code | 023155 | ||
| Instructor(s) | |||||
| 黒田 裕, 浅野 竜太郎 [KURODA Yutaka, ASANO Ryutaro] | |||||
| Facility affiliation | Faculty of Engineering | Office | afjgxte/L1151 | Email address | |
| Course description |
|
Students will learn about the basics of immunology, and the recent findings. I addition we wil discuss the immune system in relation to cancer and allergy. In the second part (Antibody Engineering) industrial applications of proteins involved in immunity will be discussed. The aim of this lecture is to understand the structure, function and diversity of proteins involved in immunity especially antibodies, and also to learn how these molecules have been successfully applied as molecular target drugs. |
| Expected Learning |
|
1) Understanding the basics of immunology 2) understanding the structure, function and diversity of antibodies, cytokines, and explain how to obtain them. 3) explain correctly the engineering application examples of protein involved in immunity. |
| Course schedule |
|
Immunology: Lecture 1: Introduction to the immune system Lecture 2: Innate immunity Lecture 3: Acquired immunity Lecture 4.B cells, T cell and immunity related molecules Lecture 5; TLR, etc Lecture 6 Bacteria, Viruses, and Immune Response Lecture 7:Immune Response and Disease: Allergy, autoimmune response, cancer Antibody Engineering: Lecture 8: Structure, function, and preparation of antibodies Lecture 9: Antibody engineering - humanized antibodies, catalytic antibodies and so on- Lecture 10: Immunoengineering - chimeric antigen receptors, modified cytokines and so on- Lecture 11: Fragment antibodies and antibody-like molecules Lecture 12: Conjugate antibodies and fusion antibodies Lecture 13: Development of bispecific antibodies Lecture 14: Development of next-generation cancer therapeutic antibodies |
| Prerequisites |
| Basics of Biochemistry, molecular biology and protein chemistry |
| Required Text(s) and Materials |
| How the IMMUNE SYSTEM works Lauren Sompayrac, Wiley Blackwell,4600円(Amazon) |
| References |
|
Kuby Immunology ペーパーバック ? 9300円(Amazon) Janeway's Immunobiology ペーパーバック ? 10300円(Amazon) |
| Assessment/Grading |
| The students will be evaluated by their performances on class participation (50%) and home works, quizzes, and reports (50%). |
| Message from instructor(s) |
| Course keywords |
| Office hours |
| Remarks 1 |
| Remarks 2 |
| Related URL |
| Googleclass: afjgxte |
| Lecture Language |
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| Last update |
| 4/14/2022 3:57:12 PM |