Course title
ケミカルバイオロジー   [Chemical Biology]
Course category technology speciality courses  Requirement   Credit 1 
Department   Year 34  Semester 1st 
Course type 1st  Course code 023164
Instructor(s)
櫻井 香里, 寺 正行   [SAKURAI Kaori, TERA Masayuki]
Facility affiliation Faculty of Engineering Office   Email address

Course description
Class code:yvgusdv

In Chemical Biology, as a specialized chemistry course, students are expected to be able to understand the basics of chemical structures and synthesis methods of sugars, amino acids, nucleic acids, that constitute biological macromolecules, natural products, and drugs as well as the basics of the mechanisms of interaction between biological macromolecules and small molecules, from the viewpoint of the properties of organic compounds and their reactivity with biological substances.

In this course, chemical properties and reactivity of sugars, amino acids, and nucleic acids, which are the unit structures of major biomacromolecules, will be lectured. Methods for synthesizing natural and artificial biomolecules using these reactions are also addressed. The latest chemical biology methods for the design of functional biomolecules and their applications in biological research and drug discovery will be introduced. In addition, we will deepen our understanding of the interactions of natural products and drugs with proteins and nucleic acids, and of the basic mechanisms by which drugs work. Quiz-type assignments will be given in each lecture. Through this lecture, students will learn how to use the electron arrows to understand reactions.
Expected Learning
Understand the structure and reaction properties of glycans, nucleic acids, amino acids, and natural products. This subject corresponds to the viewpoint A of the diploma policy.
Course schedule
1: Carbohydrates (1)
2: Carbohydrates (2)
3: Chemical Biology of Glycans
4: Amino acids, Peptides and Proteins (1)
5: Amino Acids, Peptides and Proteins (2)
6: Amino Acids, Peptides and Proteins (3)
7: Chemical Biology of Protein-Ligand Interactions
8: Final exam (1-7)
9: Natural Products Chemistry (1)
10: Natural Products Chemistry (2)
11: Chemical Biology of Natural Products Chemistry
12: Nucleic Acid Structure
13: Nucleic Acid Chemistry
14: Chemical Biology of Nucleic Acids
15: Final exam (9-14)

Prerequisites
This lecture is a series of chemistry courses, following "Basic Chemistry", "Organic Chemistry in Life Science I", "Organic Chemistry in Life Science II" and "Medicinal Chemistry". You are encouraged to take those lectures for the “Chemical Biology”.
Required Text(s) and Materials
Wade Organic Chemistry (Maruzen) and Supplementary materials.
天然物の化学II(自然からの贈り物)(東京化学同人)
References
Some texts and Books will be introduced in the course.
生体有機化学(東京化学同人)、天然物の化学(魅力と展望)(東京化学同人)
Assessment/Grading
Evaluation will be made based on the results of the report (30%) and the final exam (70%).
Message from instructor(s)
Modern organic chemistry is not limited to small molecules, but has also developed into a field that deals with various biomacromolecules. How can we synthesize biomolecules? By using organic synthesis, it is possible to synthesize artificial biomolecules with new designs and to express desired biological functions. How do drugs work? Understanding why drugs work and the mechanisms by which they work at the molecular level will lead to the discovery of new drugs. Through these lectures, we hope that you will learn the fascination and breadth of organic chemistry, which aims to understand and control life phenomena.
Course keywords
carbohydrates, amino acids, nucleic acids, natural products
Office hours
Remarks 1
Remarks 2
Related URL
Lecture Language
Japanese
Language Subject
Last update
3/15/2022 11:44:01 AM