| Course title | |||||
| 卒業論文 [Graduation Thesis] | |||||
| Course category | technology speciality courses | Requirement | Credit | 8 | |
| Department | Year | 4～4 | Semester | YearLong | |
| Course type | YearLong | Course code | 024109 | ||
| Instructor(s) | |||||
| 篠原 恭介 [SHINOHARA Kyosuke] | |||||
| Facility affiliation | Faculty of Engineering | Office | Email address | ||
| Course description |
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Objective: Students are expected to obtain the appropriate thinking and fundamental skills in the conduct of each research activities. Overview: Students will be performed in cutting-edge research areas by each corresponding laboratory. Moreover, the students should compile the graduation thesis and give the presentation at the end of term. This subject is associated with Perspective C of the Diploma Policy. |
| Expected Learning |
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（1）To obtain the methods for attainment of the purpose of their own research. （2）To obtain the presentation technique for understanding audience by summarizing results. （3）To obtain the preparation techniques of reports and articles. |
| Course schedule |
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Saito Laboratory: Disease model cells of diabetes. / Regenerative cell engineering. ES cells. / Single-cell gene engineering. / Femtoinjection. / Food safety control and regulatory science. Kuroda Laboratory: Structural and functional analysis of proteins at atomic/molecular level using recombinant DNA technologies, NMR, X-ray crystallography, and computational simulation. Biophysical studies of protein aggregation. Tsugawa Hiroshi Laboratory: Our laboratory explores new biological phenomena from the viewpoint of "metabolism". Furthermore, we attempt to apply our approach to industrial applications. For this purpose, it is important to know how to approach the underlying biological questions and hypotheses, and how to interpret the results obtained. In this laboratory, we will elucidate the complex metabolic systems of living organisms based on two approaches: one is an omics science approach using mass spectrometry, and the other is a computational science approach to analyze the large-scale data. Ikebukuro, Tsuawa and Asano Laboratory: Nucleic acid engineering of aptamers for the application to diagnosis and novel bottom-up nanotechnology. / Biomolecular engineering for the development of 1) novel enzymes for the diagnostic application,and 2) novel proteins for the application in the synthetic biology. Development of novel biodevices for the creation of theranostic platforms and environmental monitoring systems. Inada Laboratory: Investigations of refractory diseases for clinical drug development are employed for lifestyle-related diseases such as Cancer, Osteoporosis, Rheumatoid Arthritis and Periodontitis. Functional analysis of molecular biochemistry using mammalian cell to individuals is promoted research. Moreover, the molecular pathological investigation using gene targeted mice and disease models on mice. Ohta Laboratory: Development of novel techniques for organelle imaging and their application to mitochondrial study. Cell death, Ca2+ signaling and generation of reactive oxygen species are mainly focused. Yamada Laboratory: Molecular biological and biochemical studies on the enzymes involved in plant secondary metabolisms. / Molecular biological analysis of the genes based on the function of the proteins related to salt-tolerance phenotype of the halophyte. Nakazawa Laboratory: Structural analysis of silk fibroins using solid state NMR techniques. / Development of the medical implantation devices such as artificial cardiac valves and cardiovascular patches based on the silk fibroin. Kawano Laboratory: The goal of our research is to establish a system that uses biological nanopores for single-molecule detection. Channel membrane proteins have nanochannels around 1 nm in size. These biological nanopores are capable of detecting and electrically recognize even single molecules with a high signal-to-noise ratio. However, the channel size is limited by the inherent protein structure. I plan to develop artificial nanochannels such as synthetic nanopores or polypeptides combined with biomaterials (proteins and lipid bilayers) on the basis of MEMS technology for novel nanopore sensing. Mori Laboratory: Elucidating the function of environmental microbes using genomic and transcriptomic analyses. Development of a novel technique for specific isolation of microbes from the environment and the establishment of a system using cell penetrating peptides used for elucidation of gene regulation, the function of hypothetical proteins and Tanaka, Arakaki and Yoshino Laboratory: - Production of biofuels, chemicals and pharmaceuticals on the basis of biological functions of various microorganisms. /Development of Bio-sensing system based on lab-on-a-chip technologies. / Molecular analysis of biomineralization mechanism. Biomimetic synthesis of organic/inorganic hybrid nanomaterials using biological molecules. / Development of novel bio-nanomaterials through genetic engineering by microorganisms for biosensing and biomedical applications. Nakamura Laboratory: Bioelectrochemistry and Raman spectroscopy of metalloproteins and construction of biofuel cells. Ichikawa Laboratory: New design and synthesis of amphipathic molecules showing self-organization behavior. Investigation of their self-organization behavior and molecular assembly behavior. Investigating the correlation between molecular assembled nanostructures and function for developing innovative materials. Nagasawa and Tera Laboratory: Total synthesis of biologically active natural products. Development of organocatalyst. Sakurai Laboratory: Development of novel chemical tools to study biological functions of glycolipids and natural products. Yohda, Shinohara and Noguchi Laboratory: Structure and function of molecular chaperones. Genetic analysis systems for SNP genotyping and bioremediation. / Structure and function of metalloenzymes. Protein X-ray crystallography. Nakamura, Nakamura and Kim Laboratory: Cell engineering based on nanotechnology aiming to use iPS cells or somatic stem cells practically for the regenerative medicine. Genome engineering based on high-throughput genome analysis aiming to make fine products from the gene resources of Aspergillus oryzae used for Japanese traditional fermentation industries or the related species. |
| Prerequisites |
| The student must be the member of corresponding laboratory. |
| Required Text(s) and Materials |
| None |
| References |
| None |
| Assessment/Grading |
| The students will be evaluated by the research(30%) and seminar in each laboratory(30%), ability of presentation(40%). |
| Message from instructor(s) |
| Course keywords |
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| Last update |
| 2/2/2022 2:04:38 PM |